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Emerging drugs for the treatment of onychomycosis

Aditya K Gupta1,2, Nadia Stec1

  • 1Mediprobe Research Inc, London, Ontario, Canada.

Expert Opinion on Emerging Drugs
|October 26, 2019
PubMed

Insights

Onychomycosis, a persistent nail fungal infection, presents treatment challenges. Emerging topical therapies and improved patient adherence offer better outcomes for this common condition.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Onychomycosis is a prevalent, chronic, and recurrent nail fungal infection.
  • Caused by dermatophytes, molds, and yeasts, it traditionally requires systemic antifungal treatment.
  • Recent research focuses on topical formulations due to challenges with systemic therapies.

Purpose of the Study:

  • To review the current market for onychomycosis antifungal treatments.
  • To explore novel treatments in development or experimental phases.
  • To highlight the trend towards topical options and penetration enhancers.

Main Methods:

  • Literature review of current and emerging onychomycosis treatments.
  • Analysis of market trends and research in antifungal therapies.
  • Examination of systemic and topical treatment approaches.

Main Results:

  • The antifungal market includes established systemic options and developing topical formulations.
  • Penetration enhancers are being investigated to improve topical treatment efficacy.
  • Novel systemic treatments are also under development.

Conclusions:

  • Despite advancements, onychomycosis remains difficult to cure due to fungal biofilms and incomplete understanding of the fungal lifecycle.
  • High cure rates are achievable with patient adherence to treatment and preventative measures.
  • The shift towards topical treatments and novel systemic options shows promise.
Keywords:
Antifungaldermatophytefungusitraconazoleonychomycosisterbinafinetinea unguium

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