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Updated: Jan 5, 2026

Small and Wide Angle X-Ray Scattering Studies of Biological Macromolecules in Solution
Published on: January 8, 2013
Angular X-Ray Cross-Correlation Analysis (AXCCA): Basic Concepts and Recent Applications to Soft Matter and
Ivan A Zaluzhnyy1,2, Ruslan P Kurta3, Marcus Scheele4,5
1Department of Physics, University of California San Diego, La Jolla, San Diego, CA 92093, USA. ivan.zaluzhnyy@gmail.com.
Abstract:
Angular X-ray cross-correlation analysis (AXCCA) is a technique which allows quantitative measurement of the angular anisotropy of X-ray diffraction patterns and provides insights into the orientational order in the system under investigation. This method is based on the evaluation of the angular cross-correlation function of the scattered intensity distribution on a two-dimensional (2D) detector and further averaging over many diffraction patterns for enhancement of the anisotropic signal. Over the last decade, AXCCA was successfully used to study the anisotropy in various soft matter systems, such as solutions of anisotropic particles, liquid crystals, colloidal crystals, superlattices composed by nanoparticles, etc. This review provides an introduction to the technique and gives a survey of the recent experimental work in which AXCCA in combination with micro- or nanofocused X-ray microscopy was used to study the orientational order in various soft matter systems.
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