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Ralstonia mannitolilytica sepsis: a case report
Michael Owusu1,2, Godfred Acheampong2, Augustina Annan2,3
1Department of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Background:
Ralstonia mannitolilytica is an emerging opportunistic pathogen that is associated with severe disease, including septic shock, meningitis, and renal transplant infections. Reports on this pathogen are limited, however, especially on the African continent.
Case Presentation:
A 2-year-old Akan child was presented to a hospital in the northeastern part of Ghana with a 1-week history of fever and chills. We identified Ralstonia mannitolilytica in her blood culture using both conventional and 16S ribosomal deoxyribonucleic acid (rDNA) techniques. The patient's condition improved clinically upon treatment with cefuroxime.
Conclusion:
Our report highlights the potential of Ralstonia mannitolilytica to cause sepsis and thus emphasizes the need for improved laboratory diagnosis and evidence for use of appropriate antibiotics in rural settings of Africa, where presumptive treatment using antimicrobial agents is rife.
Insights
Ralstonia mannitolilytica, an emerging pathogen, caused sepsis in a Ghanaian child. This case highlights the need for better diagnostics and antibiotic stewardship in Africa.
Area of Science:
- Medical Microbiology
- Infectious Diseases
Background:
- Ralstonia mannitolilytica is an emerging opportunistic pathogen.
- It is associated with severe diseases like septic shock and meningitis.
- Limited reports exist, particularly from Africa.
Observation:
- A 2-year-old child in Ghana presented with fever and chills.
- Ralstonia mannitolilytica was identified in blood cultures using conventional and 16S ribosomal DNA methods.
- The patient showed clinical improvement after cefuroxime treatment.
Findings:
- This case confirms R. mannitolilytica as a cause of sepsis.
- Successful treatment with cefuroxime was observed.
- Highlights the pathogen's presence in an underreported region.
Implications:
- Emphasizes the need for enhanced laboratory diagnostics for R. mannitolilytica in Africa.
- Stresses the importance of evidence-based antibiotic selection over presumptive treatment.
- Underscores the potential for severe infections in vulnerable populations in rural settings.
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