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Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
Published on: November 24, 2017
Neurologic Injury in Neonates Undergoing Cardiac Surgery
Dean B Andropoulos1, Ronald Blaine Easley1, Erin A Gottlieb2
1Department of Pediatric Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Houston, TX, USA; Departments of Anesthesiology and Pediatrics, Baylor College of Medicine, 6551 Main St. E 1940, Houston, TX 77030-3411, USA.
Abstract:
Neurodevelopmental outcomes after neonatal congenital heart surgery are significantly influenced by brain injury detectable by MRI imaging techniques. This brain injury can occur in the prenatal and postnatal periods even before cardiac surgery. Given the significant incidence of new MRI brain injury after cardiac surgery, much work is yet to be done on strategies to detect, prevent, and treat brain injury in the neonatal period in order to optimize longer-term neurodevelopmental outcomes.

