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Effect of isotretinoin on eccrine gland function.
The British Journal of Dermatology
|July 1, 1988
Summary
Isotretinoin treatment did not significantly alter stimulated sweat secretion rates in patients. While some patients showed a slight increase, the changes were not clinically apparent or statistically significant.
Area of Science:
- Dermatology
- Physiology
Background:
- Isotretinoin is a common acne medication.
- Altered sweat secretion is a potential side effect of some medications.
Purpose of the Study:
- To investigate the effect of isotretinoin on stimulated sweat secretion.
Main Methods:
- Sweat secretion was stimulated using pilocarpine iontophoresis.
- Measurements were taken before and during isotretinoin treatment in 20 patients.
Main Results:
- 15 out of 20 patients (75%) showed an increase in sweat secretion.
- The mean increase was 15%, which was not statistically significant (P=0.085).
- No clinically significant alterations in sweating were observed.
Conclusions:
- Isotretinoin therapy does not appear to cause important changes in stimulated sweating.
- Further research may be needed to confirm these findings in larger populations.