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Robust organic nanoparticles for noninvasive long-term fluorescence imaging
Yuyao Guan1, Tingting Sun, Jun Ding
1Department of Radiology, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, Jilin 130033, P. R. China. dingjun@jlu.edu.cn.
Journal of Materials Chemistry. B
|October 29, 2019
Summary
Researchers explored novel organic nanoparticles for non-invasive, long-term fluorescence imaging, addressing limitations of current agents like indocyanine green (ICG). This review highlights materials based on aggregation-caused quenching and aggregation-induced emission for advanced bioimaging applications.
Area of Science:
- Biomedical Imaging
- Materials Science
- Nanotechnology
Background:
- Fluorescence imaging offers sensitive, selective visualization of cellular components.
- Indocyanine green (ICG) is the only FDA-approved intravenous fluorescent agent.
- ICG's limitations necessitate the development of new fluorescent materials.
Purpose of the Study:
- To review and highlight organic nanoparticles for non-invasive, long-term bioimaging.
- To discuss fluorescent nanoparticles based on aggregation-caused quenching (ACQ) and aggregation-induced emission (AIE) mechanisms.
- To identify future challenges and opportunities for clinical translation.
Main Methods:
- Literature review of organic nanoparticles for fluorescence bioimaging.
- Categorization of nanoparticles based on fluorescence emission mechanisms (ACQ and AIE).
- Analysis of reported materials for non-invasive, long-term bioimaging applications.
Main Results:
- Numerous organic nanoparticles have been developed in the last decade.
- Nanoparticles utilizing ACQ and AIE mechanisms show promise for bioimaging.
- These materials offer alternatives to existing agents like ICG.
Conclusions:
- Organic nanoparticles represent a significant advancement in fluorescence bioimaging.
- Further research is needed to overcome challenges in material development and clinical translation.
- Optimized organic nanoparticles hold potential for improved diagnostic and therapeutic applications.
