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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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QT variability index in patients with systemic sclerosis.
Udi Nussinovitch1,2, Shiri Rubin2,3, Yair Levy2,4
1Department of Cardiology and Applicative Cardiovascular Research Center (ACRC), Meir Medical Center, Kfar Saba, Israel.
European Journal of Rheumatology
|October 29, 2019
Summary
QT variability index (QTVI) may indicate increased ventricular arrhythmia risk in a small number of systemic sclerosis (SSc) patients. Further research is needed to confirm its prognostic significance in SSc heart disease.
Area of Science:
- Cardiology
- Electrophysiology
- Systemic Sclerosis Research
Background:
- Systemic sclerosis (SSc) can cause cardiac dysfunction and early death, often due to microvascular issues.
- The role of repolarization markers in SSc heart disease is not fully understood.
- QT variability (QTVI) is an understudied marker of repolarization dynamics.
Purpose of the Study:
- To investigate QT variability (QTVI) as a potential marker in systemic sclerosis (SSc) patients.
- To assess the prognostic value of QTVI in predicting cardiac events in SSc.
- To compare QTVI between SSc patients and healthy controls.
Main Methods:
- A prospective study included 17 SSc patients and 21 healthy controls.
- Standardized electrocardiograms were performed.
- QT variability index (QTVI), normalized QT variability (QTVN), and power spectral analysis were calculated using specialized software.
Main Results:
- No significant differences in clinical parameters or mean QTVI, QTVN, and power spectral analysis were observed between SSc patients and controls.
- One SSc patient with a history of ventricular arrhythmia showed markedly elevated QTVI at baseline.
- No arrhythmias occurred in the remaining SSc patients or controls during an 8-year follow-up.
Conclusions:
- Elevated QTVI may occur in a subset of SSc patients.
- The prognostic implication of high QTVI in SSc remains uncertain but may suggest a higher risk of ventricular arrhythmias.
- Further investigation into QTVI for arrhythmia risk stratification in SSc is warranted.
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