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Bioprinting for Liver Transplantation
Christina Kryou1, Valentina Leva2, Marianneza Chatzipetrou3
1Department of Physics, National Technical University of Athens, 15780 Zografou, Greece. chkryou@central.ntua.gr.
Bioengineering (Basel, Switzerland)
|October 30, 2019
Summary
Direct writing bioprinting techniques enable the creation of complex 3D cellular structures, particularly for liver tissue engineering. These methods are crucial for developing advanced liver models for pharmaceutical testing.
Area of Science:
- Biotechnology
- Tissue Engineering
- Regenerative Medicine
Background:
- Bioprinting facilitates in vitro fabrication of complex functional bio-structures.
- Extensive research is ongoing for developing 3D cellular structures using various techniques.
Purpose of the Study:
- To focus on direct writing bioprinting techniques for cell structure fabrication.
- To highlight the application of bioprinting in creating 2D and 3D liver models and liver-on-a-chip platforms.
Main Methods:
- Discussion of three direct writing bioprinting techniques: laser-based, ink-jet, and extrusion bioprinting.
- Review of materials used in liver tissue engineering for fabricating functional liver structures.
Main Results:
- Bioprinting techniques offer versatile methods for constructing intricate cellular architectures.
- Specific focus on the development of liver models for pharmaceutical research due to the liver's critical metabolic and detoxification roles.
Conclusions:
- Direct writing bioprinting is a key technology for advancing liver tissue engineering.
- The development of sophisticated liver models using bioprinting is vital for drug discovery and toxicity assessment, potentially reducing drug rejection rates.
