Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy
Alexandra Audemard-Verger1,2, Jacques Gasnault1,3, Maxime Faisant4
1Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Open Forum Infectious Diseases
|October 30, 2019
Abstract:
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.
