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Updated: Jan 4, 2026

Rapid Identification of Gram Negative Bacteria from Blood Culture Broth Using MALDI-TOF Mass Spectrometry
Published on: May 28, 2014
Blood Culture-Negative Cardiovascular Infection in a Patient With Multiple Sclerosis
Cléa Melenotte1,2, Ahmed Loukil1,2, Audrey Rico3
1Aix-Marseille Univ, IRD, APHM, MEPHI, Marseille, France.
Abstract:
A patient with multiple sclerosis presented with seronegative C. burnetii endocarditis diagnosed using C. burnetii-specific polymerase chain reaction and fluorescence in situ hybridization on cardiovascular biopsy. This case supports the necessity of a systematic polymerase chain reaction testing of removed cardiac valves because blood culture-negative endocarditis can be pauci-symptomatic, and serological tests can be negative in cases of immunosuppression.
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