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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Updated: Jan 4, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Novel Tumor-Microenvironment-Based Sequential Catalytic Therapy by Fe(II)-Engineered Polydopamine Nanoparticles.

Yuda Zhu¹, Nini Xin¹, Zi Qiao¹

¹National Engineering Research Center for Biomaterials , Sichuan University , Sichuan , Chengdu 610064 , P. R. China.

ACS Applied Materials & Interfaces

|October 30, 2019

Summary

This study developed a novel nanosystem using polydopamine (PDA) that targets the tumor microenvironment (TME). It combines glucose degradation, Fenton reactions, and photothermal therapy for effective cancer treatment with fewer side effects.

Keywords:

Fenton reaction cascade catalysis glucose oxidase hydrothermal method polydopamine tumor microenvironment

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Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Therapy

Background:

Traditional cancer treatments have significant side effects and limited efficacy.
The tumor microenvironment (TME) presents unique opportunities for targeted cancer therapies.
Developing safer and more effective cancer treatment strategies is crucial.

Purpose of the Study:

To fabricate a polydopamine (PDA)-based nanosystem responsive to the tumor microenvironment (TME).
To integrate glucose degradation, Fenton reaction, and photothermal therapy for enhanced cancer treatment.
To create a TME-specific nanomedicine with minimal side effects.

Main Methods:

Fabrication of Fe(II)-PDA nanoparticles via a hydrothermal method.
Grafting glucose oxidase (GOD) onto Fe(II)-PDA nanoparticles to form Fe(II)-PDA-GOD.
Utilizing the cascade reaction of glucose degradation and Fenton reaction for hydroxyl radical generation.
Employing photothermal therapy in conjunction with the nanosystem.

Main Results:

Fe(II)-PDA nanoparticles exhibited excellent photothermal properties and Fenton reactivity.
Fe(II)-PDA-GOD effectively catalyzed glucose into gluconic acid and hydrogen peroxide (H2O2) in the TME.
Generated H2O2 enhanced the Fenton reaction, producing cytotoxic hydroxyl radicals (•OH).
Intratumoral glucose consumption by the nanosystem inhibited tumor growth.
In vitro and in vivo studies demonstrated synergistic antitumor effects.

Conclusions:

The developed Fe(II)-PDA-GOD nanosystem offers a TME-responsive platform for cancer therapy.
This approach integrates multiple therapeutic modalities for enhanced efficacy and reduced side effects.
The study expands the application of PDA in biomedicine and provides novel strategies for effective antitumor treatment.