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Related Experiment Video

Updated: Jan 4, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

A pilot exploratory study comparing the King-Devick test (KDT) during and between migraine attacks.

Chia-Chun Chiang¹, Amaal J Starling¹, Matthew R Buras²

¹Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.

Cephalalgia : an International Journal of Headache

|October 30, 2019

Summary

This summary is machine-generated.

The King-Devick test, a measure of complex brain function, was significantly slower during migraine attacks compared to non-attack periods. This cognitive slowing was more pronounced in individuals with migraine with aura.

Keywords:

King-Devick test migraine attack migraine-related disability rapid eye movement

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Area of Science:

Neurology
Cognitive Neuroscience

Background:

The King-Devick test assesses rapid number naming, involving intricate cerebral functions.
Migraine is a neurological disorder often associated with cognitive changes.

Purpose of the Study:

To investigate performance differences in the King-Devick test during active migraine attacks versus interictal phases.
To explore the King-Devick test's potential as a biomarker for migraine-related disability.

Main Methods:

A pilot study involving 29 adult migraineurs (with and without aura).
King-Devick tests were administered during both migraine attacks and interictal periods.
Participants served as their own controls to minimize inter-individual variability.

Main Results:

King-Devick test performance was significantly impaired during migraine attacks (median 4.6 seconds slower; p < 0.001).
Cognitive slowing on the King-Devick test was more substantial in participants with migraine with aura (median 7.5 seconds) compared to those without aura (median 2.8 seconds; p = 0.028).

Conclusions:

The King-Devick test demonstrates measurable changes in cognitive function during migraine attacks.
Further research is warranted to validate the King-Devick test as a simple, objective tool for assessing migraine-associated disability.