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Mycophenolate Mofetil-induced Oral Ulcerations in a Kidney Transplant Recipient
Hanène Gaied1,2, Mohamed Mongi Bacha2,3, Tasnim Mesbahi3
1Department of Nephrology, Mongi Slim Hospital, La Marsa, Tunisia.
Current Drug Safety
|October 30, 2019
Summary
Mycophenolate Mofetil (MMF) can cause rare but painful mouth ulcers in kidney transplant patients. Stopping MMF led to rapid healing, suggesting it as a potential cause.
Area of Science:
- Immunology
- Pharmacology
- Gastroenterology
Background:
- Mycophenolate Mofetil (MMF) is a key immunosuppressant for kidney transplant recipients.
- Common MMF side effects include leucopenia, anemia, and diarrhea.
- Mouth ulcers are an infrequently reported adverse effect of MMF.
Observation:
- A case report details a 41-year-old African male experiencing painful oral ulcers 5 months post-kidney transplant.
- The patient was on a maintenance regimen of steroids, tacrolimus, and MMF.
- Initial treatments for presumed fungal/viral infections were ineffective.
Findings:
- Tacrolimus blood levels were within the therapeutic range.
- Discontinuation of MMF resulted in rapid resolution of the oral ulcers.
- This suggests MMF as the causative agent for the mouth ulcers.
Implications:
- Oral ulcers are common in immunosuppressed patients but rarely linked to MMF.
- Severe oral ulcers significantly impair quality of life.
- When infections are ruled out, MMF should be considered a potential cause of drug-induced oral ulcers.
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