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Related Experiment Video

Updated: Jan 4, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
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[Hormone and breast cancer].

Anne Gompel1

  • 1Université Paris-Descartes, Gynécologie, 123, boulevard de Port-Royal, 75014 Paris, France.

Presse Medicale (Paris, France : 1983)
|October 31, 2019
PubMed
Summary

Hormone therapies, including contraception and menopause treatments, can promote existing breast cancer lesions. Combining hormone therapy with anti-estrogens may reduce breast cancer risk while retaining estrogen benefits.

Area of Science:

  • Oncology
  • Endocrinology
  • Reproductive Health

Background:

  • Most breast cancers are hormone-dependent, responding to hormonal influences.
  • Hormone treatments like contraception and menopausal hormone therapy can affect pre-existing breast cancer lesions.

Purpose of the Study:

  • To analyze the impact of various hormone treatments on breast cancer risk.
  • To investigate the relationship between hormone therapy duration and breast cancer risk.
  • To explore potential strategies for mitigating hormone therapy-associated breast cancer risks.

Main Methods:

  • Review of existing literature on hormone treatments and breast cancer.
  • Analysis of risk factors associated with hormonal contraception and menopausal hormone therapy.
  • Examination of breast cancer characteristics in relation to hormone treatment.

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Main Results:

  • Hormonal contraception shows a modest increase in risk for current users, more pronounced in women over 40.
  • Menopausal hormone therapy, particularly combined therapy, is linked to increased breast cancer risk, which escalates with duration.
  • Hormone treatment-associated breast cancers are predominantly estrogen receptor-positive.

Conclusions:

  • Hormone treatments can promote pre-existing breast cancer lesions, with risk diminishing post-treatment cessation.
  • Pregnancy's effect on risk varies by age, potentially increasing it after 25.
  • Combining hormone therapy with anti-estrogens may offer a way to reduce breast cancer risk while preserving therapeutic benefits.