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Updated: Jan 4, 2026

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

Published on: August 15, 2012

Circulating Monocytes, Tissue Macrophages, and Malaria.

Nida Ozarslan¹, Joshua F Robinson², Stephanie L Gaw^2,3

¹Marmara University School of Medicine, Istanbul, Turkey.

Journal of Tropical Medicine

|October 31, 2019

Summary

This summary is machine-generated.

Malaria infection involves the Plasmodium parasite interacting with monocytes and macrophages in various organs. This review explores these interactions and their impact on malaria outcomes.

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Area of Science:

Immunology
Infectious Diseases
Parasitology

Background:

Malaria remains a major global health burden, causing significant morbidity and mortality.
The Plasmodium parasite exhibits a complex life cycle involving mosquito, liver, and blood stages.
Blood-stage malaria can target organs like the brain and placenta.

Purpose of the Study:

To review the interactions between Plasmodium parasites and monocytes/macrophages.
To summarize knowledge on malaria's effects on specific immune cells in key organs.
To highlight potential roles of these interactions in disease outcomes and suggest future research directions.

Main Methods:

Literature review of current knowledge on malaria and immune cell interactions.
Focus on monocytes and tissue-specific macrophages (Kupffer cells, microglia, placental macrophages).
Analysis of cellular and molecular changes resulting from parasite-immune cell interactions.

Main Results:

Plasmodium parasites interact with monocytes and macrophages during various life cycle stages and in affected organs.
These interactions induce changes in immune cells, including cytokine release and receptor expression.
Specific immune cells discussed include Kupffer cells (liver), microglia (CNS), and placental macrophages.

Conclusions:

Monocytes and macrophages play crucial roles in modulating malaria infection outcomes.
Understanding these host-parasite interactions is vital for developing effective malaria control strategies.
Further research is needed to fully elucidate the complex interplay between malaria and the innate immune system.