Primary colon mantle lymphoma: a misleading macroscopic appearance!

Area of Science:

• Gastroenterology
• Oncology
• Pathology

Background:

• Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma.
• Colonic MCL typically manifests as lymphomatous polyposis.

Observation:

• A 43-year-old male presented with an atypical colonic MCL.
• The lesion was a solitary, exophytic, ulcerous mass with necrosis.
• It was associated with an ileocecal intussusception.

Findings:

• Endoscopic examination suggested adenocarcinoma.
• Histology and immunohistochemistry confirmed Mantle cell lymphoma.
• This case highlights an unusual presentation of colonic MCL.

Implications:

• Atypical presentations of colonic MCL can mimic adenocarcinoma.
• Histopathological and immunohistochemical analyses are crucial for accurate diagnosis.
• This case expands the understanding of colonic MCL morphology.