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TRIM45 Suppresses the Development of Non-small Cell Lung Cancer

Xiyang Peng1, Yao Wen2, Lagabaiyila Zha3

  • 1Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, College of Physical Education, Hunan Normal University, Changsha, Hunan 410012, China.

Current Molecular Medicine
|October 31, 2019
PubMed
Abstract

Insights

Human tripartite motif-containing protein 45 (TRIM45) inhibits lung cancer development. TRIM45 promotes apoptosis and inhibits proliferation by modulating MAPK signaling in non-small-cell lung cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Human tripartite motif-containing protein 45 (TRIM45) identified as a transcriptional repressor in MAPK signaling.
  • TRIM45's inhibitory role in tumor development was previously suggested.
  • The specific function of TRIM45 in lung cancer tumorigenesis remained uncharacterized.

Purpose of the Study:

  • To investigate the role of TRIM45 in the tumorigenesis of lung cancer.
  • To elucidate the molecular mechanisms by which TRIM45 affects lung cancer cells.

Main Methods:

  • Analysis of TRIM45 expression in early-stage non-small-cell lung cancer (NSCLC) tissues.
  • Overexpression of TRIM45 in lung cancer cells to assess its effects on cell cycle and apoptosis.
  • Examination of downstream signaling molecules in the MAPK pathway, including p38 and ERK.

Main Results:

  • TRIM45 was found to be upregulated in early-stage NSCLC tissues.
  • TRIM45 overexpression induced G1 arrest and apoptosis, altering the expression of key cell cycle and apoptosis regulators.
  • TRIM45 modulated MAPK signaling by promoting p-p38 activation and inhibiting p-ERK activation in lung cancer cells.

Conclusions:

  • TRIM45 plays an inhibitory role in lung cancer tumorigenesis.
  • High TRIM45 expression in lung cancer promotes apoptosis via p38 activation and inhibits proliferation via p-ERK downregulation.
  • TRIM45 represents a potential therapeutic target for lung cancer treatment.
Keywords:
MAPK pathwayNSCLCTRIM45apoptosisinhibitory rolelung cancer.

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