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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus
Mateus Kawata Salgaço1, Liliane Garcia Segura Oliveira2, Giselle Nobre Costa2
1Department of Food and Nutrition, School of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, SP, Brazil.
Applied Microbiology and Biotechnology
|October 31, 2019
Summary
Type 2 diabetes mellitus (T2DM) is rising globally. This review explores how gut microbiota composition influences T2DM and discusses the potential of probiotics in managing this condition.
Area of Science:
- Microbiology
- Endocrinology
- Gastroenterology
Background:
- Type 2 diabetes mellitus (T2DM) prevalence is increasing worldwide, posing significant public health challenges.
- Established risk factors include lifestyle, diet, and genetics.
- Emerging research suggests a link between intestinal microbiota composition and T2DM development.
Purpose of the Study:
- To review the current understanding of the relationship between intestinal microbiota and T2DM.
- To discuss the role of probiotics in modulating the gut microbiota for T2DM management.
Main Methods:
- Literature review of recent studies on gut microbiota, probiotics, and T2DM.
- Synthesis of findings on the mechanisms linking microbiota dysbiosis to T2DM.
Main Results:
- Evidence indicates that alterations in gut microbiota composition are associated with T2DM.
- Probiotics show potential in modulating gut microbiota, potentially impacting T2DM.
Conclusions:
- The gut microbiota plays a crucial role in the pathogenesis of T2DM.
- Probiotics represent a promising therapeutic avenue for T2DM, warranting further investigation.
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