Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Recombinant DNA

Recombinant DNA

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

Genetic Material

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Coping with primary brain tumors together: a scoping review of dyadic psychosocial interventions.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Same author

The Earth BioGenome Project Phase II: illuminating the eukaryotic tree of life.

Frontiers in science·2026

Same author

Database resources of the National Center for Biotechnology Information in 2026.

Nucleic acids research·2025

Same author

Distress and Emotional Support Needs of Patients With Stage IV Cancer and Their Partners: A Biopsychosocial Assessment.

Psycho-oncology·2025

Same author

Understanding the relationship between body image and emotional distress among men and women with cancer.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2025

Same author

GenBank 2025 update.

Nucleic acids research·2024

Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026

Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026

Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026

Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026

Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026

Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 4, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

GenBank.

Eric W Sayers¹, Mark Cavanaugh¹, Karen Clark¹

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research

|October 31, 2019

Summary

This summary is machine-generated.

GenBank® is a vast public nucleotide sequence database, updated daily with global partners. Recent enhancements improve usability for viral genomes and pathogen data submission.

More Related Videos

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Related Experiment Videos

Last Updated: Jan 4, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

GenBank® is a critical public repository for nucleotide sequences.
It houses over 1.6 billion sequences from 450,000 species, totaling 6.25 trillion base pairs.
Daily data synchronization with ENA and DDBJ ensures comprehensive global coverage.

Purpose of the Study:

To report on the current state and recent updates of the GenBank® database.
To highlight improvements in data submission and management tools.
To emphasize the collaborative nature of global nucleotide sequence archiving.

Main Methods:

Data aggregation from global partners including ENA and DDBJ.
Development and implementation of new software versions (Genome Workbench).
Enhancements to submission tools (BankIt, viral genome wizards) and taxonomy handling.

Main Results:

GenBank® now exceeds 1.6 billion nucleotide sequences.
New Genome Workbench version facilitates GenBank submissions.
Improved submission wizards for viral genomes and enhanced taxonomy handling for pathogens.

Conclusions:

GenBank® remains a cornerstone resource for biological research, continuously updated and improved.
Recent enhancements streamline data submission and improve data quality, particularly for viral and pathogen sequences.
International collaboration ensures the database's global relevance and comprehensive nature.