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The Colton blood group locus. A linkage analysis
1Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Transfusion
|September 1, 1988
Summary
This study investigated the Colton blood group locus (CO) location, finding no evidence for linkage on chromosomes 1, 3, 4, 6, or 19. The proposed chromosome 2 location for the Colton blood group is questioned.
Area of Science:
- Human Genetics
- Molecular Biology
- Immunogenetics
Background:
- The Colton blood group locus (CO) is a significant marker in human genetics.
- Previous studies have proposed a chromosomal location for the CO locus, necessitating further verification.
Purpose of the Study:
- To accurately determine the chromosomal location of the Colton blood group locus (CO).
- To investigate potential linkage of the CO locus with other polymorphic markers.
Main Methods:
- Utilized accumulated family information for genetic analysis.
- Performed two-point linkage analysis between the CO locus and 46 other polymorphic loci.
- Evaluated linkage disequilibrium with specific genetic markers.
Main Results:
- Excluded the Colton blood group locus (CO) from several chromosomal regions, including 1p36-1q23, 3q21-3q26, 4q13-4q28, 6p24-6cen, and 19p13.2-19cen.
- Reinforced diminishing odds of linkage between CO and the JK locus.
- Failed to demonstrate close linkage between CO and ACP1 and D2S5 markers.
Conclusions:
- The proposed chromosomal location of the Colton blood group locus (CO) on chromosome 2 is not supported by this linkage analysis.
- Further studies are required to definitively establish the chromosomal localization of the Colton blood group locus.