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Updated: Jan 4, 2026
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Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
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Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests
Sho Suzuki1,2, Hiroshi Kawakami1,3, Tadashi Miike1,2
1Department of Gastroenterology and Hematology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|November 1, 2019
Summary
Rectal neuroendocrine tumors (NETs) are rare. This case highlights a single rectal NET with multiple endocrine cell micronests (ECMs), treated successfully with endoscopic resection and showing no metastasis six years later.
Area of Science:
- Gastroenterology
- Endocrinology
- Oncology
Background:
- Neuroendocrine tumors (NETs) are neoplasms originating from endocrine cells.
- Rectal NETs are uncommon, with limited published data, especially concerning associated micronests.
- Endocrine cell micronests (ECMs) are rare findings around NETs, and their clinical significance is not well understood.
Observation:
- A unique case of a single rectal neuroendocrine tumor (NET) is presented.
- The patient underwent successful endoscopic treatment for the rectal NET.
- Pathological examination revealed multiple endocrine cell micronests (ECMs) in the submucosal layer adjacent to the primary NET lesion.
Findings:
- The patient showed no evidence of lymph node or distant metastasis six years post-treatment.
- Computed tomography confirmed the absence of metastatic disease.
- This report details a rare instance of multiple ECMs associated with a rectal NET.
Implications:
- The rarity of multiple ECMs associated with rectal NETs makes their prognostic significance unclear.
- Further accumulation of similar cases is necessary to understand the clinical implications and malignancy potential of rectal NETs with multiple ECMs.
- Endoscopic treatment may be a viable option for selected cases of rectal NETs with associated ECMs.
