Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.1K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.1K
Morphogenesis02:19

Morphogenesis

30.1K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.1K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.5K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.5K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Inflammatory bowel disease uncovered in fecal immunochemical test positive patients in a Canadian provincial colon cancer screening program.

Scientific reports·2026
Same author

Inflammatory bowel disease uncovered in fecal immunochemical test positive patients in a Canadian provincial colon cancer screening program.

Scientific reports·2024
Same author

A novel hypothesis about mechanism of thalidomide action on pattern formation.

Bio Systems·2024
Same author

C3/CD11b-Mediated Leishmania major Internalization by Neutrophils Induces Intraphagosomal NOX2-Mediated Respiratory Burst but Fails to Eliminate Parasites and Induces a State of Stalled Apoptosis.

Journal of immunology (Baltimore, Md. : 1950)·2023
Same author

Developmental graphs comparison strategy for analysis of pattern formation and phylogeny.

Journal of theoretical biology·2021
Same author

Determinism and variability of the morphogenesis pathways.

Developmental biology·2021

Related Experiment Video

Updated: Jan 4, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

2.6K

Morphogenesis software based on epigenetic code concept.

Nikolay Bessonov1, Oksana Butuzova2, Andrey Minarsky3

  • 1IPME RAS, St-Petersburg, Russia.

Computational and Structural Biotechnology Journal
|November 1, 2019
PubMed
Summary

This study proposes that epigenetic information guides organismal shape changes during development and regeneration. A new software simulates embryo development, demonstrating how epigenetic rules can regulate morphogenesis and pattern formation.

More Related Videos

Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

8.2K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.9K

Related Experiment Videos

Last Updated: Jan 4, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

2.6K
Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

8.2K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.9K

Area of Science:

  • Developmental Biology
  • Computational Biology
  • Systems Biology

Background:

  • Morphogenesis, the process of organismal shape evolution and part differentiation, is crucial for embryogenesis and regeneration.
  • A key question is how developmental instructions are stored and executed, particularly concerning the geometry of shape changes.

Purpose of the Study:

  • To propose a theoretical framework for understanding the geometry of morphogenesis based on epigenetic information.
  • To develop and present a software tool for simulating embryo development based on these theoretical assumptions.

Main Methods:

  • Formalizing development as a graph of cell states connected by cell events (division, growth, death, movement, differentiation).
  • Utilizing epigenetic information as the basis for cell states and cell event rules.
  • Developing a 3D simulation software to model embryo evolution from a zygote.

Main Results:

  • The Morphogenesis software simulates 3D embryo development based on epigenetic rules and cell event dynamics.
  • The simulation provides a proof-of-concept for the hypothesis that epigenetic code regulates morphogenesis.
  • The model demonstrates how variations in developmental rules influence resulting embryo shape and pattern formation.

Conclusions:

  • Epigenetic information plays a fundamental role in regulating the process of morphogenesis.
  • The developed computational model offers a tool to explore the laws governing pattern formation and developmental processes.
  • This work provides a mathematical formalization and simulation approach to the geometry of morphogenesis.