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Sacubitril/valsartan in heart failure and end-stage renal insufficiency

Alex Heyse1, Lynn Manhaeghe1, Elien Mahieu2

  • 1Department, of Cardiology, AZ Glorieux, Ronse, Belgium.

ESC Heart Failure
|November 1, 2019
PubMed

Insights

Sacubitril/valsartan treatment was feasible and safe for a patient with severe heart failure on hemodialysis. The medication improved heart failure symptoms, reduced NT-proBNP levels, and decreased filling pressures.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Severe heart failure with reduced ejection fraction (HFrEF) in patients undergoing hemodialysis presents significant therapeutic challenges.
  • Renal insufficiency and hemodialysis complicate the management of HFrEF due to altered drug pharmacokinetics and potential for adverse effects.

Keywords:
ARNIChronic kidney diseaseDialysisHeart failureSacubitril/valsartan

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