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[Protein engineering: from directed evolution to computational design].

Ge Qu¹, Tong Zhu², Yingying Jiang¹

¹Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology

|November 1, 2019

Summary

This summary is machine-generated.

Computer-assisted protein design, including directed evolution and computational methods, is revolutionizing protein engineering. Artificial intelligence is further enhancing these techniques for novel enzyme development and improved protein functions.

Keywords:

artificial intelligence computational design energy function protein engineering simulation of structure

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Area of Science:

Biochemistry
Protein Engineering
Computational Biology

Background:

Directed evolution is a leading strategy for protein design.
Computer-assisted protein design has advanced significantly due to increased computing power and algorithms.
Machine learning and AI are emerging as powerful tools in computational protein engineering.

Purpose of the Study:

To review the progress and applications of computer-assisted protein design.
To discuss current trends and future outlooks in the field of protein engineering.

Main Methods:

Construction of mutant libraries and high-throughput screening for directed evolution.
Protein structure simulation and energy function calculations for computational design.
Application of machine learning and artificial intelligence in protein engineering.

Main Results:

Computational design can modify enzyme substrate specificity and thermostability.
De novo design of artificial enzymes with desired functions is achievable.
Remarkable applications have arisen from AI integration in computational protein engineering.

Conclusions:

Computer-assisted protein design is a powerful and rapidly developing field.
The integration of AI promises further breakthroughs in protein engineering.
Future developments will likely focus on advanced computational and AI-driven approaches for novel protein functionalities.