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[Systems biology for industrial biotechnology].
Xiaomei Zheng1,2,3, Ping Zheng1,2,3, Jibin Sun1,2,3
1Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|November 1, 2019
Summary
Systems biology transforms industrial biotechnology by enabling a deeper understanding of microbial cell factories. Omics technologies provide valuable insights for developing sustainable bioprocesses and products from renewable resources.
Area of Science:
- Industrial biotechnology
- Systems biology
- Synthetic biology
Background:
- Microbial cell factories are crucial for sustainable production of chemicals, materials, and energy from renewable resources.
- Industrial biotechnology addresses global resource, energy, and environmental challenges.
- Systems biology enhances understanding of microbial cell factories and bioprocesses, moving from a "black-box" to a "white-box" approach.
Purpose of the Study:
- To review recent advances and applications of omics and trans-omics technologies in industrial biotechnology.
- To highlight the role of systems biology in optimizing microbial cell factories and industrial bioprocesses.
- To discuss the future potential and promise of systems biology in advancing industrial biotechnology.
Main Methods:
- Genome-wide profiling (genomics, transcriptomics, proteomics, metabolomics, fluxomics).
- Genome-scale modeling.
- Integration of multi-omics data for systems-wide analysis.
- Application of systems biology principles to microbial strain engineering.
Main Results:
- Systems-wide omics profiling provides deep insights into microbial network operation and regulation.
- Systems biology approaches have been successfully applied to engineer microbial cell factories for diverse products.
- These advancements accelerate the development of efficient and attractive industrial bioprocesses.
Conclusions:
- Systems biology, powered by omics technologies, is revolutionizing industrial biotechnology.
- The integration of multi-omics data and modeling is key to designing and optimizing microbial cell factories.
- Continued application of systems biology promises further innovation in sustainable biomanufacturing.
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