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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Food Allergy Testing.

Nicole A LaHood¹, Sarita U Patil²

¹Allergy and Immunology, Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA, USA.

Clinics in Laboratory Medicine

|November 1, 2019

Summary

This summary is machine-generated.

Diagnosing immunoglobulin E (IgE)-mediated food allergies relies on oral food challenges, but biomarkers like serum-specific IgE and skin prick tests are helpful. Newer component-resolved diagnostics offer further insights into food sensitization.

Keywords:

Component testing Food allergy Immunoglobulin E Oral food challenge Skin testing

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Area of Science:

Allergy and Immunology
Diagnostic Biomarkers
Food Hypersensitivity

Background:

Oral food challenges are the gold standard for diagnosing immunoglobulin E (IgE)-mediated food allergies.
Existing biomarkers, including serum-specific IgE and skin prick testing, assist in clinical diagnosis.
Defined clinically useful values exist for individual food allergens.

Purpose of the Study:

To review the clinical utility of current biomarkers for IgE-mediated food allergy.
To highlight the evolving landscape of food allergy diagnostics.
To emphasize the role of specific IgE to protein components.

Main Methods:

Review of existing literature on food allergy diagnostics.
Analysis of the diagnostic value of serum-specific IgE and skin prick tests.
Evaluation of component-resolved diagnostics for food allergens.

Main Results:

Serum-specific IgE and skin prick tests are clinically relevant biomarkers aiding food allergy diagnosis.
Established reference values enhance the utility of these diagnostic tests.
IgE testing against specific protein components offers improved diagnostic precision.

Conclusions:

Current diagnostic methods for evaluating IgE sensitization in food allergies are clinically useful.
The field of food allergy diagnostics is continuously advancing.
Component-resolved diagnostics represent a significant evolution in evaluating IgE-mediated food allergies.