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Microfluidics in Assessing Platelet Function
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A Novel Platelet Function Assay for Trauma.

Mitchell J George1, Kevin R Aroom2, Charles E Wade1

  • 1Department of Surgery, McGovern Medical School, The University of Texas Health Science Center, Houston, Texas.

The Journal of Surgical Research
|November 1, 2019
PubMed
Summary
This summary is machine-generated.

Platelet contraction force is a novel test that shows hyperfunction in trauma survivors and dysfunction in non-survivors, unlike other tests. This finding may help predict survival in critically injured patients.

Keywords:
MortalityPlatelet contractionThrombelastography

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Area of Science:

  • Biomedical Engineering
  • Trauma Research
  • Hematology

Background:

  • Existing platelet function tests show universal dysfunction in trauma patients.
  • Platelet contraction force is introduced as a novel measure of platelet function.
  • Hypothesis: contraction force correlates with coagulation tests and differentiates patient groups.

Purpose of the Study:

  • Introduce and validate platelet contraction force as a diagnostic tool.
  • Compare contraction force between healthy subjects and trauma patients.
  • Assess the potential of contraction force to identify critically ill trauma patients.

Main Methods:

  • Prospective collection of blood samples from trauma patients.
  • Assay of platelet contraction force and time to contraction.
  • Comparison with thrombelastography and healthy control subjects.

Main Results:

  • Trauma survivors (n=90) showed significantly higher platelet contraction force than healthy controls (n=12) and non-survivors (n=10).
  • Faster time to platelet contraction observed in survivors compared to both healthy controls and non-survivors.
  • Contraction force differed significantly between surviving trauma patients, non-survivors, and healthy individuals.

Conclusions:

  • Platelet contraction force reveals hyperfunction in trauma survivors, contrasting with existing tests indicating dysfunction.
  • Platelet contraction force may serve as a biomarker for survival post-trauma, reflecting metabolic reserve.
  • Further research is warranted to establish contraction force for mortality prediction in severe trauma.