Related Experiment Video
Updated: Jul 1, 2026

On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
Understanding the Effect of Transfusion Rates on Differential Modulation of Inflammatory Responses
Patrick R Carney1, Ben L Zarzaur1, John B Holcomb2
1Department of Surgery, University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin.
Introduction:
The immediate postinjury immune response contributes in a complex manner to trauma-induced coagulopathy. The necessary transfusion of blood components can further impact a patient's immune response, creating a poorly understood cycle of transfusion, inflammation, and coagulopathy. The purpose of this study is to define the relationship between large volume transfusion and variations in the immune response following injury.
Methods:
Utilizing the Pragmatic, Randomized Optimal Platelet and Plasma Ratios trial dataset, the time and volume of transfused blood products were compared to patients' inflammatory cascade for 72 h following injury. In order to model variations in the times and volumes of transfused blood products, time-varying effect modeling was used to assess cytokine response.
Results:
A total of 522 patients were included in the analysis. A statistically significant correlation in IL 6, IP 10, MIP 1B, and RANTES levels was observed in response to volume and tempo of blood product administration.
Conclusions:
Cytokine levels in the acute post-traumatic period are related to blood product transfusion in a time- and volume-dependent manner, specifically showing increases in proinflammatory cytokine and chemokine signaling. An understanding of how blood product administration affects these cytokine signatures can help guide resuscitation practices and represents a potentially novel target for therapeutic intervention.
More Related Videos
Related Concept Videos
Acute Inflammation III: Local and Systemic Effects
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Regulation of Hematopoietic Stem Cells
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

