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Updated: Jan 4, 2026

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
Published on: December 7, 2017
Induction of membrane curvature by proteins involved in Golgi trafficking
Stefanie L Makowski1, Ramya S Kuna1, Seth J Field1
1Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA, 92093, USA.
Abstract:
The Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Golgi to promote vesicular trafficking to various cellular destinations.
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