Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Washing, Drying, and Ignition of Precipitates00:52

Washing, Drying, and Ignition of Precipitates

5.0K
After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
5.0K
Colloidal precipitates01:09

Colloidal precipitates

4.6K
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
4.6K
Intermolecular Forces and Physical Properties02:56

Intermolecular Forces and Physical Properties

26.0K
26.0K
Colloids03:22

Colloids

20.5K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
20.5K
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility02:34

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility

50.0K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
50.0K
Precipitation Processes01:12

Precipitation Processes

4.5K
The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modelling the effect of L/S ratio and granule moisture content on the compaction properties in continuous manufacturing.

International journal of pharmaceutics·2023
Same author

Influence of localized thermal effects on the reconstitution kinetics of lactose-coated whole milk powder.

Food research international (Ottawa, Ont.)·2021
Same author

Twin screw granulation: A simpler re-derivation of quantifying fill level.

International journal of pharmaceutics·2020
Same author

Roller compaction: Infrared thermography as a PAT for monitoring powder flow from feeding to compaction zone.

International journal of pharmaceutics·2020
Same author

Application of feeding guiders to improve the powder distribution in the two scales of roller compactors.

International journal of pharmaceutics·2019
Same author

Assessing Particle Segregation Using Near-Infrared Chemical Imaging in Twin Screw Granulation.

International journal of pharmaceutics·2019

Related Experiment Video

Updated: Jan 4, 2026

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.6K

Wetting of binary powder mixtures.

Aquino L Mundozah1, Claire C Tridon2, James J Cartwright2

  • 1Department of Chemical and Biological Engineering, University of Sheffield, Mapping Street, Sheffield S1 3JD, UK.

International Journal of Pharmaceutics
|November 1, 2019
PubMed
Summary

Predicting liquid droplet contact angles on particle mixtures is challenging. A new geometric model accounts for small particles coating larger ones, improving wetting behavior predictions for pharmaceutical formulations.

Keywords:
Contact angleSurface coverageWetting

More Related Videos

Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices
09:31

Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices

Published on: March 27, 2019

9.9K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

23.3K

Related Experiment Videos

Last Updated: Jan 4, 2026

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.6K
Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices
09:31

Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices

Published on: March 27, 2019

9.9K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

23.3K

Area of Science:

  • Surface Science
  • Materials Science
  • Physical Chemistry

Background:

  • Wetting phenomena on particle mixtures are often analyzed using Cassie-Baxter theory.
  • Existing applications of Cassie-Baxter theory to two-component mixtures have yielded unsuccessful predictions.
  • Particle size differences can lead to smaller particles coating larger ones, altering surface area and invalidating bulk volume fraction assumptions.

Purpose of the Study:

  • To address the limitations of Cassie-Baxter theory in predicting contact angles on particle mixtures.
  • To develop a new model that accounts for particle coating effects in binary mixtures.
  • To provide a more accurate method for predicting wetting behavior in complex particulate systems.

Main Methods:

  • Hypothesized that small particles coating large particles reduces effective surface area.
  • Developed a simple geometrical model relating critical surface coverage to Sauter mean particle size.
  • Validated the model against nine experimental two-component systems from literature and the current study.

Main Results:

  • The proposed geometrical model successfully describes wetting behavior in various two-component particle systems.
  • The model accounts for systems regardless of the hydrophobicity/hydrophilicity of the constituent particles.
  • It demonstrates that Cassie-Baxter theory can overrepresent the influence of larger particles, especially below a critical volume fraction.

Conclusions:

  • A novel geometric model accurately predicts wetting behavior in particle mixtures where coating occurs.
  • This model simplifies the prediction of wetting by relating bulk properties to surface behavior.
  • The findings can reduce development time for formulations in industries like pharmaceuticals.