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Multi-directional cellular alignment in 3D guided by electrohydrodynamically-printed microlattices.

Mao Mao1, Jiankang He1, Zhi Li1

  • 1State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, China; Rapid Manufacturing Research Center of Shaanxi Province, Xi'an Jiaotong University, Xi'an, 710049, China.

Acta Biomaterialia
|November 1, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method for directing three-dimensional (3D) cellular alignment using electrohydrodynamically-printed microlattices. This technique enables the creation of complex, aligned multicellular tissue constructs with potential applications in regenerative medicine.

Keywords:
Cardiac patchCellular alignmentCollagen hydrogelElectrohydrodynamic printingMicrolattice

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Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Cellular Biology

Background:

  • Recapitulating native tissue architecture is crucial for developing functional artificial tissues.
  • Achieving controlled three-dimensional (3D) cellular alignment remains a significant challenge in tissue engineering.

Purpose of the Study:

  • To present a novel strategy for directing 3D cellular alignment within hydrogels using electrohydrodynamically-printed microlattices.
  • To demonstrate the ability to engineer anisotropic multicellular tissue constructs with predefined cellular orientations.

Main Methods:

  • Embedding cell/collagen hydrogel into electrohydrodynamically-printed microlattices.
  • Investigating the influence of microlattice geometry (height, spacing, orientation) on cellular alignment.
  • Utilizing layer-specific microlattice orientations for multilayered constructs with varied cellular orientations.

Main Results:

  • The cell/collagen hydrogel spontaneously formed densely-populated, highly-aligned bands along the microlattice's longitudinal direction.
  • Cellular alignment was dependent on microlattice dimensions and orientation.
  • The method successfully aligned multiple cell types, including primary cardiomyocytes, and facilitated the creation of anisotropic multicellular constructs.
  • Engineered cardiac patches exhibited mature phenotypes and synchronous contractions.
  • Multilayered constructs with varied cellular orientations in 3D collagen hydrogel were successfully fabricated.

Conclusions:

  • Electrohydrodynamically-printed microlattices provide a novel, stimulus-free approach to direct 3D cellular and collagen fiber alignment.
  • This strategy enables the engineering of complex 3D tissue constructs with precise control over cellular organization.
  • The developed method holds promise for fabricating biomimetic tissues with tailored mechanical and physiological functions.