Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy
Chenggui Wu1, Xinjun Yang1, Yong Shang1
1Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), College of Chemistry and Molecular Sciences , Wuhan University , 430072 Wuhan , China.
Abstract:
Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an oxa-cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the molecular complexity rapidly and efficiently from feedstock chemicals, this method will have wide applications in organic synthesis.
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