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Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury
Published on: August 3, 2015
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Cell senescence contributes to tissue regeneration in zebrafish
Sabela Da Silva-Álvarez1, Jorge Guerra-Varela2,3, Daniel Sobrido-Cameán4
1Laboratorio de Células Madre en Cáncer y Envejecimiento, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
Aging Cell
|November 1, 2019
Summary
Cellular senescence, a cell cycle arrest, promotes tissue repair and homeostasis. In zebrafish, senescent cells appear after fin injury, and their removal hinders regeneration, highlighting senescence
Area of Science:
- Cellular and Molecular Biology
- Regenerative Medicine
- Aging Research
Background:
- Cellular senescence is a stress-induced permanent cell cycle arrest.
- Accumulation of senescent cells is linked to aging and disease.
- However, senescence also plays positive roles in development and tissue repair.
Purpose of the Study:
- To investigate the role of tissue injury-induced senescence in zebrafish fin regeneration.
- To determine if senescence is conserved as a pro-regenerative mechanism in complex regeneration models.
Main Methods:
- Zebrafish fin amputation model.
- Induction and identification of senescent cells at the injury site.
- Pharmacological clearance of senescent cells to assess impact on regeneration.
Main Results:
- Senescent cells were observed at the site of fin amputation in adult zebrafish.
- Removal of these senescent cells significantly impaired the regeneration process.
- Tissue repair response involving senescence differs from developmental senescence.
Conclusions:
- Cellular senescence is a conserved, positive response that promotes tissue repair and homeostasis.
- Senescence acts as a crucial pro-regenerative force in complex regeneration, such as zebrafish fin repair.
