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Updated: Jan 4, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
Natalie Patel1, Andrea Barbieri2, Joanna Gibson3
1Gastrointestinal and Pancreaticobiliary Pathology, Department of Pathology, Yale School of Medicine, Yale New Haven Hospital, 20 York Street, New Haven, CT 06510, USA.
Abstract:
Neuroendocrine neoplasms (NENs) of the gastrointestinal (GI) tract and pancreas are a rare and heterogeneous group of neoplasms characterized by common cellular features as well as unique site-specific traits. GI and pancreatic NENs are much rarer than the more common adenocarcinomas arising at these sites. However, the incidences of GI and pancreatic NENs have increased significantly, particularly in the stomach and common site, followed by rectum, appendix, colon, and stomach. Pancreatic NENs are also uncommon, with fewer than 1 per 100,000, accounting for 1% to 2% of all pancreatic neoplasms.
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