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Updated: Jan 4, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Chiral Separation of Styrene Oxides Supported by Enantiomeric Tetrahedral Neutral Pd(II) Cages
Prabhakaran Rajasekar, Swechchha Pandey1, Joseph D Ferrara2
1Polymer Science and Engineering Division , CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road , Pune 411008 , India.
Abstract:
The separation of enantiomers is of considerable importance in the preparation of the compounds of biological interests, catalysis, and drug development. Here, we report a novel enantioseparation of styrene epoxides (SOs) resolved in the presence of a pair of enantio-enriched tetrahedral cages. Chiral neutral cages of formula [(Pd3X*)4(C6O4Cl2)6] ([X*]3- = RRR- or SSS-[PO(N(*CH(CH3)Ph)3]3-) are constructed from Pd3 building units supported by tris(imido)phosphate trianions and chloranilate linkers. These cages exhibit considerable enantioselective separation capabilities toward a series of styrene epoxides via a crystallization inclusion method. A highest enantiomeric excess (ee) value of up to 80% is achieved for the (R)-4-fluorostyrene oxide.
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