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Outstanding questions in transplantation: Tolerance
Joseph R Leventhal1, James M Mathew1,2
1Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, Illinois, USA.
Summary
This review explores clinical transplantation tolerance, a key topic from the American Society of Transplantation forum. It covers historical context and current research efforts to achieve tolerance in patients.
Area of Science:
- Transplantation immunology
- Clinical research
Background:
- The American Society of Transplantation (AST) established a research forum in 2017 to foster dialogue between clinicians and researchers.
- Transplantation tolerance has been identified as a critical area for advancement within the field.
Purpose of the Study:
- To provide an overview of clinical transplantation tolerance.
- To review the historical background and current status of tolerance induction in clinical transplantation.
- To highlight discussions from the AST Transplantation Research forum.
Main Methods:
- Literature review focusing on clinical transplantation tolerance.
- Analysis of discussions and themes from the AST Transplantation Research forum.
Main Results:
- Tolerance is a significant area of interest for the transplantation community.
- The review synthesizes historical perspectives with contemporary clinical efforts.
Conclusions:
- Continued dialogue between clinicians and researchers is essential for advancing transplantation tolerance.
- The AST forum serves as a platform for dynamic discussion on critical transplantation topics.
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