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Transplant Patients' Perceptions About Participating in First-in-Human Pig Kidney Xenotransplant Clinical Trials: A
Elisa J Gordon1, Karen J Maschke2, Jessica Gacki-Smith3
1Department of Surgery, and Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Xenotransplantation
|February 6, 2025
Summary
Patient willingness for pig kidney xenotransplantation trials is low due to concerns about safety and function. Understanding these patient attitudes is crucial for ethical informed consent in future xenotransplant research.
Area of Science:
- Transplantation research
- Medical ethics
- Patient decision-making
Background:
- First-in-human pig xenotransplantation trials are imminent.
- Ethical considerations regarding patient participation and informed consent are paramount.
Purpose of the Study:
- To assess kidney transplant candidates' attitudes towards participating in xenotransplantation trials.
- To understand hypothetical decision-making processes for xenotransplant trial enrollment.
Main Methods:
- Semi-structured telephone interviews with 28 patients.
- Online survey completed by 142 patients.
- Qualitative thematic analysis and quantitative descriptive statistics.
Main Results:
- Most participants expressed concerns regarding infection transmission and graft function.
- Low willingness was reported for trials focused on pig kidney safety (12.6%) or function (16.9%).
- Willingness increased if human kidney availability was unlikely and health declined, contingent on graft longevity.
Conclusions:
- Transplant programs must address patient concerns about infection, graft function, and monitoring.
- A robust informed consent process is essential for optimizing human subject protections in xenotransplantation trials.
Keywords:
attitudesdecision‐makingefficacyethicsinformed consentpatient‐centeredqualitativerecruitmentsafetysurveyMore Related Videos
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