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Programming hMSCs into Potential Genetic Therapy in Cancer
Nedime Serakinci1, Huseyin Cagsin2
1Near East University, Faculty of Medicine, Department of Medical Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus; Near East University, Faculty of Arts and Sciences, Dept. of Molecular Biology and Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus.
Human mesenchymal stem cells (hMSCs) show promise for cancer therapy due to their tumor-homing ability. Genetically modified hMSCs offer enhanced antitumor effects by delivering therapeutic agents, potentially improving cancer treatment outcomes.
Area of Science:
- Oncology
- Stem Cell Biology
- Gene Therapy
Background:
- Human mesenchymal stem cells (hMSCs) possess unique self-renewal and differentiation capabilities.
- hMSCs exhibit a notable tropism for primary and metastatic tumor sites.
- Adult stem cells are emerging as potential vehicles for novel cancer therapies.
Purpose of the Study:
- To review the potential of genetically modified hMSC-based gene therapy for cancer treatment.
- To explore the advantages of combining stem cell and gene therapy approaches.
- To highlight the therapeutic capabilities of hMSCs in oncology.
Main Methods:
- Review of recent studies on stem cell-mediated cancer therapy.
- Analysis of genetically modified MSCs for antitumor effects.
- Focus on hMSC-based genetic therapy strategies.
Main Results:
- Genetically modified MSCs can enhance apoptosis and reduce tumor growth and angiogenesis.
- hMSCs serve as effective delivery vehicles for therapeutic agents to tumor sites.
- Stem cell-mediated delivery shows potential for improved antitumor effects.
Conclusions:
- Genetically modified hMSC-based gene therapy presents a promising approach for cancer treatment.
- This combined therapy leverages the homing ability of hMSCs and gene delivery mechanisms.
- hMSC-based strategies may offer advantages over existing cancer therapies.
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