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Programming hMSCs into Potential Genetic Therapy in Cancer

Nedime Serakinci1, Huseyin Cagsin2

  • 1Near East University, Faculty of Medicine, Department of Medical Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus; Near East University, Faculty of Arts and Sciences, Dept. of Molecular Biology and Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus.

Critical Reviews in Eukaryotic Gene Expression
|November 4, 2019
PubMed

Insights

Human mesenchymal stem cells (hMSCs) show promise for cancer therapy due to their tumor-homing ability. Genetically modified hMSCs offer enhanced antitumor effects by delivering therapeutic agents, potentially improving cancer treatment outcomes.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Gene Therapy

Background:

  • Human mesenchymal stem cells (hMSCs) possess unique self-renewal and differentiation capabilities.
  • hMSCs exhibit a notable tropism for primary and metastatic tumor sites.
  • Adult stem cells are emerging as potential vehicles for novel cancer therapies.

Purpose of the Study:

  • To review the potential of genetically modified hMSC-based gene therapy for cancer treatment.
  • To explore the advantages of combining stem cell and gene therapy approaches.
  • To highlight the therapeutic capabilities of hMSCs in oncology.

Main Methods:

  • Review of recent studies on stem cell-mediated cancer therapy.
  • Analysis of genetically modified MSCs for antitumor effects.
  • Focus on hMSC-based genetic therapy strategies.

Main Results:

  • Genetically modified MSCs can enhance apoptosis and reduce tumor growth and angiogenesis.
  • hMSCs serve as effective delivery vehicles for therapeutic agents to tumor sites.
  • Stem cell-mediated delivery shows potential for improved antitumor effects.

Conclusions:

  • Genetically modified hMSC-based gene therapy presents a promising approach for cancer treatment.
  • This combined therapy leverages the homing ability of hMSCs and gene delivery mechanisms.
  • hMSC-based strategies may offer advantages over existing cancer therapies.

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