Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Accuracy of dual-energy computed tomography (CT), ultrasound, cone-beam CT, and spectral photon-counting CT for detecting calcium crystal deposition in the osteoarthritic hand: a cross-sectional diagnostic test study.

Scandinavian journal of rheumatology·2026

Same author

Computer-Assisted Dynamic Contrast-Enhanced Magnetic Resonance Imaging Quantification Method for Assessment of Synovial Inflammation in Active Arthritis: Correlation With Synovial and Blood Biomarkers.

ACR open rheumatology·2026

Same author

Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort.

European journal of epidemiology·2025

Same author

Exploratory study of predictors of decreased ability to perform activities of daily living in people living with hand osteoarthritis.

Scandinavian journal of rheumatology·2025

Same author

Translation, cross-cultural adaptation, and reliability of the EULAR Systemic Sclerosis Impact of Disease (ScleroID) questionnaire in a Danish population.

Scandinavian journal of rheumatology·2025

Same author

Advancing Inflammatory Bowel Disease Treatment by Targeting the Innate Immune System and Precision Drug Delivery.

International journal of molecular sciences·2025

Search research articles

Related Experiment Video

Updated: Jan 4, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Weight Loss Intervention Before Total Knee Replacement: A 12-Month Randomized Controlled Trial.

A Liljensøe¹, J O Laursen², H Bliddal³

¹Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Denmark.

Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society

|November 5, 2019

Summary

A pre-surgery weight loss diet for obese patients undergoing total knee replacement is safe and feasible. While not statistically significant, the intervention group maintained weight loss and improved body composition one year post-surgery.

Keywords:

Obesity joint replacement knee osteoarthritis leptin quality of life weight loss

More Related Videos

The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation

The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation

Published on: July 22, 2019

Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction

Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jan 4, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation

The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation

Published on: July 22, 2019

Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction

Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction

Published on: March 1, 2024

Area of Science:

Orthopedics
Obesity Medicine
Metabolic Health

Background:

Obesity is a growing concern for patients undergoing total knee replacement (TKR).
Excess weight can negatively impact surgical outcomes and patient recovery.

Purpose of the Study:

To evaluate the impact of a pre-operative weight loss intervention on quality of life, knee function, mobility, and body composition one year after primary TKR.
To assess the feasibility and safety of an intensive low-energy diet prior to TKR in obese patients.

Main Methods:

Randomized controlled trial comparing a standard care group with an 8-week low-energy diet intervention group before TKR.
Outcomes including patient-reported quality of life, 6-Minute Walk Test, and body composition (DXA) were assessed pre-intervention and one year post-surgery.
A reduced sample size may have limited statistical power to detect significant differences.

Main Results:

Both groups showed significant improvements in quality of life and knee function one year after TKR.
The intervention group achieved an average weight loss of 10.7 kg (6.7 kg fat mass) during the 8-week pre-operative diet.
Weight loss was maintained in the diet group at one year, while the control group showed no change.

Conclusions:

An intensive pre-operative weight loss program is feasible and safe for obese patients scheduled for TKR.
The intervention led to substantial weight loss, improved body composition, and reduced cardiovascular risk factors.
Sustained weight reduction and improved metabolic markers suggest potential long-term benefits.