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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Left Ventricular Layer-Specific Myocardial Strains in Children with Recovered Primary Dilated Cardiomyopathy: What

Enas Maher1, Waleed Elshehaby1, Doaa El Amrousy2

  • 1Pediatric Department, Tanta University Hospital, Tanta, Egypt.

Pediatric Cardiology
|November 5, 2019
PubMed

Insights

Children with recovered dilated cardiomyopathy (DCM) show subtle cardiac dysfunction, even when conventional tests appear normal. Layer-specific strain analysis reveals reduced left ventricular (LV) function, highlighting the need for long-term monitoring.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Echocardiography

Background:

  • Dilated cardiomyopathy (DCM) can affect children, with recovery often assessed by conventional echocardiography.
  • Residual cardiac dysfunction may persist despite clinical and echocardiographic recovery in pediatric DCM patients.
  • Left ventricular (LV) layer-specific myocardial strain offers a detailed assessment of cardiac function.

Purpose of the Study:

  • To detect subclinical cardiac dysfunction in children with recovered primary DCM.
  • To evaluate the utility of LV layer-specific myocardial strain in identifying residual LV dysfunction.
  • To compare cardiac function between recovered DCM children and healthy controls using advanced echocardiographic techniques.

Main Methods:

  • Fifty children with recovered DCM and 50 healthy controls underwent comprehensive echocardiography.
  • Techniques included conventional echocardiography, tissue Doppler imaging (TDI), and 2D speckle tracking echocardiography (2D-STE).
  • LV layer-specific myocardial strain was measured from endocardium to epicardium.

Main Results:

  • Conventional echocardiography showed similar LV systolic and diastolic function in both groups.
  • TDI revealed significant reductions in LV systolic and diastolic function in the recovered DCM group.
  • 2D-STE demonstrated reduced LV global longitudinal systolic strain (GLSS) and layer-specific strains in recovered DCM patients.
  • A significant reduction in LV layer-specific myocardial strain was observed from endocardium to epicardium in recovered DCM children.

Conclusions:

  • Subtle, yet significant, LV systolic and diastolic dysfunction persists in children with recovered DCM.
  • LV layer-specific myocardial strain is a sensitive tool for early detection of residual cardiac dysfunction in pediatric DCM.
  • Long-term follow-up is recommended for children with recovered DCM to monitor for subtle cardiac abnormalities.

Keywords:
ChildrenDilated cardiomyopathyLayer-specific strain

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