First Report of the Clinical Use of a Commercial Automated System for Daily Patient QA Using EPID Exit Images

To characterize the clinical utility of a new commercially available system for daily patient treatment quality assurance using electronic portal imaging detector (EPID) exit dose images.

The PerFRACTION automated quality assurance system was used to acquire integrated EPID images for every field every day for 60 treatment courses for 57 patients. Four thousand seventy-nine field values from 855 fractions were analyzed. Gamma passing rates were computed by the system for each field daily. Passing rates and pass-fail status were recorded by treatment modality (intensity modulated radiation therapy or 3-dimensional conformal radiotherapy) and location. When failures occurred, an attempt was made to determine the reason.

Overall, 23% and 8% of fields failed at 2%/2 mm and 3%/3 mm, respectively. Forty-eight percent and 24% of fields failed at least once during the course of therapy for the 2 tolerance settings. Eighteen percent and 8% of all fractions failed and 60% and 28% of courses failed for the 2 tolerance settings, respectively. Eighteen percent of daily field passing rates were below 75% for 3%/3 mm tolerances. Intensity modulated radiation therapy had higher passing rates than 3-dimensional conformal radiation therapy. For 3%/3 mm tolerances, the fraction fail rate for the brain, extremity, and spine treatment sites failed the least, whereas the abdomen, chest, and head and neck failed more often. The most commonly identified reason for failure was body position change, but the reason for about half the daily field value failures could not be identified.

This is the first report of the clinical utility of a commercial daily patient treatment quality assurance system using EPID exit images. Variations were found in a clinically relevant percentage of images, and these potentially indicate important treatment variations. Reasons for failures are not always discernable. The system was practical to use because of automation and continues to be used for monitoring of nearly every patient in every field every day.