The frequency of low-risk morbilliform drug eruptions observed in patients treated with different classes of

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Andrew J Krispinsky1, Lydia B Shedlofsky2, Benjamin H Kaffenberger1

  • 1Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

International Journal of Dermatology
|November 5, 2019
PubMed

Insights

Antibiotic-induced skin reactions are common, ranging from mild rashes to severe reactions. This review details the prevalence of morbilliform eruptions linked to frequently prescribed antibiotics, aiding in causality assessments.

Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Antibiotics are frequently prescribed globally, but commonly cause cutaneous adverse events.
  • Cutaneous adverse drug reactions (ADRs) vary in severity, from morbilliform eruptions to severe cutaneous adverse reactions (SCARs).
  • Diagnosing antibiotic-induced ADRs is challenging in hospitalized patients due to polypharmacy and lack of specific hypersensitivity testing.

Purpose of the Study:

  • To review the prevalence of morbilliform eruptions associated with commonly prescribed antibiotics.
  • To provide data that aids in assessing causality for antibiotic-associated drug eruptions.
  • To summarize findings from systematic reviews, retrospective, and prospective analyses.

Main Methods:

  • Systematic reviews of antibiotic-associated cutaneous adverse events.
  • Retrospective and prospective analyses of drug eruptions.
  • Inclusion of case series and reports for detailed information.

Main Results:

  • The review summarizes the prevalence of morbilliform eruptions for frequently prescribed antibiotics.
  • Data facilitates causality assessments in complex hospital settings.
  • Highlights the need for understanding eruption prevalence in drug safety evaluations.

Conclusions:

  • Antibiotic-associated drug eruptions are a significant concern.
  • Prevalence data is crucial for clinical decision-making and causality assessment.
  • Further research into diagnostic methods for delayed-type hypersensitivity is warranted.

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