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Related Concept Videos

Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

3.3K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Cycloaddition Reactions: MO Requirements for Thermal Activation01:16

Cycloaddition Reactions: MO Requirements for Thermal Activation

4.1K
Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
4.1K
Limitations of Friedel–Crafts Reactions01:26

Limitations of Friedel–Crafts Reactions

6.7K
Several restrictions limit the use of Friedel–Crafts reactions. First, the halogen in the alkyl halide must be attached to an sp3-hybridized carbon for the Friedel–Crafts reactions to occur. Vinyl or aryl halides do not react since the carbocations formed are unstable under the reaction conditions. Second, Friedel–Crafts alkylation is susceptible to carbocation rearrangement, and the major products obtained have a rearranged carbon skeleton. In contrast, the acylium ion is...
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Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation01:27

Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

2.7K
Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
2.7K
Cycloaddition Reactions: MO Requirements for Photochemical Activation01:12

Cycloaddition Reactions: MO Requirements for Photochemical Activation

2.5K
Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
2.5K
Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

37.9K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. 
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Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
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Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

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Constructing Robust Covalent Organic Frameworks via Multicomponent Reactions.

Peng-Lai Wang1, San-Yuan Ding1, Zhi-Cong Zhang1

  • 1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou , Gansu 730000 , China.

Journal of the American Chemical Society
|November 5, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed a new multicomponent reaction (MCR) strategy to create highly stable covalent organic frameworks (COFs). This method efficiently forms five covalent bonds in one pot, leading to robust imidazole-linked COFs for advanced applications.

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Area of Science:

  • Materials Science
  • Organic Chemistry
  • Nanotechnology

Background:

  • Robust linkages are crucial for synthesizing and applying covalent organic frameworks (COFs).
  • Existing methods for COF synthesis require further development for enhanced stability and complexity.
  • Multicomponent reactions (MCRs) offer a promising avenue for efficient framework construction.

Purpose of the Study:

  • To develop a novel MCR-based strategy for constructing ultrastable covalent organic frameworks (COFs).
  • To explore the formation of complex, imidazole-linked COFs using readily available starting materials.
  • To investigate the integration of sophisticated reactions for precise covalent assembly in porous frameworks.

Main Methods:

  • Utilized the Debus-Radziszewski multicomponent reaction (MCR).
  • Employed a one-pot synthesis approach for efficient bond formation.
  • Assembled imidazole-linked covalent organic frameworks (COFs) from three simple components.

Main Results:

  • Successfully constructed a series of ultrastable imidazole-linked COFs.
  • Achieved the formation of five covalent bonds per cyclic joint in a single synthetic step.
  • Demonstrated a high level of complexity and precision in the covalent assembly of porous materials.

Conclusions:

  • The developed MCR strategy provides a robust method for synthesizing highly stable COFs.
  • This approach enables the creation of intricate crystalline porous frameworks with enhanced properties.
  • Opens new directions for designing advanced materials by integrating complex reversible and irreversible reactions.