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Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous overlap of p...
Characteristics and Nomenclature of Homopolymers01:00

Characteristics and Nomenclature of Homopolymers

Polymers that are made up of identical monomer units are called homopolymers. Only one repeating unit is involved in the construction of the homopolymer structure. For example, as depicted in Figure 1, polypropylene is a homopolymer constituted of propylene monomers. Here, the only repeating unit in the polymer chain is propylene.
Carbon Skeletons01:12

Carbon Skeletons

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
Organic Compounds03:02

Organic Compounds

All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...

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Updated: Jun 3, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
08:42

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Vinylene-Linked Helical Covalent Organic Frameworks.

Lu-Yao Wang1, Jie Feng1, Rui-Lei Wang1

  • 1State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou Magnetic Resonance Center, Lanzhou University, Lanzhou, Gansu 730000, China.

Journal of the American Chemical Society
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Researchers synthesized single-handed helical covalent organic frameworks (V-heliCOFs) using a novel Siegrist olefination. These materials show strong circularly polarized luminescence, advancing chiral materials science.

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Ultrahigh Density Array of Vertically Aligned Small-molecular Organic Nanowires on Arbitrary Substrates

Published on: June 18, 2013

Area of Science:

  • Materials Science
  • Organic Chemistry
  • Supramolecular Chemistry

Background:

  • Chirality is crucial for molecular recognition and optical properties.
  • Synthesizing macroscopic chiral structures like helices in covalent organic frameworks (COFs) is challenging.
  • Existing methods often rely on reversible imine chemistry, limiting stability and uniformity.

Purpose of the Study:

  • To develop a new synthetic strategy for creating single-handed helical COFs.
  • To investigate the chiroptical properties of these novel helical COFs.
  • To establish a link between hierarchical structure and material performance.

Main Methods:

  • Utilized an unprecedented Siegrist olefination strategy for COF synthesis.
  • Formed highly uniform, single-handed macroscopic COF helices with micrometer dimensions.
  • Characterized the resulting vinylene-linked helical COFs (V-heliCOFs) for structural and optical properties.

Main Results:

  • Achieved the first synthesis of vinylene-linked helical COFs (V-heliCOFs).
  • Observed emergent circularly polarized luminescence (CPL) with a record dissymmetric factor (|g_lum|) of 1.1 × 10⁻¹.
  • Attained a high solid-state photoluminescence quantum yield (PLQY) of up to 45.7%.

Conclusions:

  • The Siegrist olefination provides a robust pathway for crystalline COF helices.
  • Hierarchical covalent assembly is effective for designing high-performance chiroptical materials.
  • Synergistic coupling of emissive frameworks and helical architecture enhances chiroptical activity.