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Meltblown Polylactic Acid Nanowebs as a Tissue Engineering Scaffold
William H Gazzola1,2,3, Roberto S Benson4, Wayne Carver1
1From the Department of General Surgery, General Surgery Residency Program, School of Medicine.
Annals of Plastic Surgery
|November 6, 2019
Summary
Meltblown polylactic acid (PLA) nanofiber nonwovens show promise as tissue engineering scaffolds. These materials support human dermal fibroblast attachment, proliferation, and migration, demonstrating potential for skin tissue regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Polylactic acid (PLA) nanofiber nonwovens mimic natural extracellular matrix.
- Electrospinning is the primary method for PLA nanoweb creation.
- Meltblown nonwovens offer an alternative fabrication route for PLA scaffolds.
Purpose of the Study:
- Evaluate meltblown PLA nanofiber webs as tissue engineering scaffolds.
- Assess fibroblast interaction with PLA scaffolds without cell adhesion molecules.
- Investigate cellular attachment, proliferation, migration, and penetration.
Main Methods:
- Fabrication of meltblown PLA fabrics with varied properties.
- Selection of a scaffold matching human dermal mechanical properties.
- In vitro assessment using MTT assay, electron microscopy, and confocal microscopy.
Main Results:
- Significant fibroblast proliferation from day 1 to 7 (P < 0.05).
- Sustained cellular attachment and surface migration over 14 days.
- Complete cellular penetration through the scaffold thickness observed.
Conclusions:
- Meltblown PLA nanofiber nonwovens are a viable scaffold for tissue engineering.
- These scaffolds support key cellular functions necessary for tissue regeneration.
- Further research into meltblown PLA scaffolds is encouraged.
