Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

6.8K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.8K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Allergic Reactions02:06

Allergic Reactions

31.9K
Overview
31.9K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.0K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

866
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
866
Cross-reactivity00:42

Cross-reactivity

32.7K
Overview
32.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging Therapies for Anaphylaxis.

Immunology and allergy clinics of North America·2026
Same author

Reply.

The Journal of allergy and clinical immunology·2026
Same author

Updates on Kinase Inhibitors in Allergy.

The journal of allergy and clinical immunology. In practice·2025
Same author

Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE.

Frontiers in immunology·2025
Same author

The Bruton tyrosine kinase inhibitor acalabrutinib aborts ongoing acute food-induced anaphylactic reactions in humanized mice.

The Journal of allergy and clinical immunology·2025
Same author

Current and future landscape of Bruton tyrosine kinase inhibitors in allergy.

The Journal of allergy and clinical immunology·2025
Same journal

Key factors in the diagnosis of sesame allergy in children.

Allergy and asthma proceedings·2026
Same journal

Immunoglobulin E-mediated pumpkin seed allergy in children: Case series and narrative review with a structured literature search.

Allergy and asthma proceedings·2026
Same journal

Predictors of delayed treatment-free remission with omalizumab in chronic spontaneous urticaria.

Allergy and asthma proceedings·2026
Same journal

The digital front door: A national analysis of U.S. allergy and immunology fellowship program web sites.

Allergy and asthma proceedings·2026
Same journal

The impact of dietary patterns on the risk of asthma in children.

Allergy and asthma proceedings·2026
Same journal

The alpha-gal syndrome: Understanding the role of tick bites, and the delays in severe anaphylaxis.

Allergy and asthma proceedings·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K

Classification of hypersensitivity reactions.

Melanie C Dispenza

    Allergy and Asthma Proceedings
    |November 7, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Hypersensitivity reactions occur when the immune system overreacts to antigens. This review details the immune mechanisms behind modern hypersensitivity classifications, updating the original Gell-Coombs system.

    More Related Videos

    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
    08:25

    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

    Published on: September 26, 2022

    3.4K
    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
    10:22

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

    Published on: September 16, 2011

    34.0K

    Related Experiment Videos

    Last Updated: Jan 4, 2026

    Humanized Mediator Release Assay as a Read-Out for Allergen Potency
    10:22

    Humanized Mediator Release Assay as a Read-Out for Allergen Potency

    Published on: June 29, 2021

    3.9K
    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
    08:25

    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

    Published on: September 26, 2022

    3.4K
    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
    10:22

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

    Published on: September 16, 2011

    34.0K

    Area of Science:

    • Immunology
    • Pathophysiology

    Background:

    • The immune system defends against pathogens but can cause damage when dysregulated.
    • Hypersensitivity describes excessive or pathogenic immune responses to self or foreign antigens.

    Purpose of the Study:

    • To review the immune mechanisms of hypersensitivity reactions.
    • To describe the modern Gell-Coombs categories of hypersensitivity.

    Main Methods:

    • Literature review of immunological mechanisms.
    • Analysis of updated hypersensitivity classifications.

    Main Results:

    • Gell and Coombs originally classified hypersensitivity into 4 types.
    • Current understanding has refined the original classification system.

    Conclusions:

    • Understanding hypersensitivity mechanisms is crucial for managing immune-related disorders.
    • This review provides an overview of current hypersensitivity categories and their underlying immune processes.