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Emerging Therapies for Anaphylaxis

Melanie C Dispenza1

  • 1Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

Immunology and Allergy Clinics of North America
|April 3, 2026
PubMed

Insights

Novel therapies are emerging to treat anaphylaxis by targeting its various underlying mechanisms. These innovative treatments, including tyrosine kinase inhibitors and new antibody-based therapies, are in clinical development for prevention and management.

Area of Science:

  • Immunology
  • Pharmacology
  • Allergy and Immunology

Background:

  • Anaphylaxis is a severe allergic reaction with diverse underlying causes.
  • Current treatments focus on symptom management, but novel approaches are needed.

Purpose of the Study:

  • To review emerging therapies for anaphylaxis prevention and treatment.
  • To discuss novel therapeutic targets and agents in clinical development.

Main Methods:

  • Review of current clinical research and development in anaphylaxis therapeutics.
  • Identification of novel drug classes and targets.

Main Results:

  • Several novel therapeutic strategies are under investigation.
  • These include tyrosine kinase inhibitors, allergen-specific blocking antibodies, and monoclonal antibodies targeting KIT or inhibitory receptors.

Conclusions:

  • New therapies targeting specific anaphylaxis pathways show promise.
  • These agents may offer improved prevention and treatment options for anaphylaxis.
Keywords:
AnaphylaxisBruton tyrosine kinaseChronic urticariaFood allergyIgEKITKinase

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