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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
Published on: March 17, 2019
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Blonanserin suppresses impulsive action in rats
Naoya Nishitani1, Hitomi Sasamori2, Yu Ohmura1
1Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638, Japan.
Journal of Pharmacological Sciences
|November 7, 2019
Summary
This study investigated potential anti-impulsivity drugs in rats. Blonanserin effectively reduced impulsive actions, while 1-(2-Pyriidinyl)-piperazine showed a slight effect but impaired motor function.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- High impulsivity is linked to increased risks of criminal behavior, drug abuse, and suicide.
- Developing effective anti-impulsivity medications is a significant challenge in psychiatric research.
Purpose of the Study:
- To evaluate the anti-impulsivity effects of two candidate drugs identified through a novel drug-screening strategy.
- To assess the efficacy and potential side effects of blonanserin and 1-(2-Pyriidinyl)-piperazine in a rat model.
Main Methods:
- Utilized a 3-choice serial reaction time task in rats to measure impulsive actions.
- Administered blonanserin (an atypical antipsychotic) and 1-(2-Pyriidinyl)-piperazine (a metabolite of buspirone/tandospirone).
Main Results:
- Blonanserin demonstrated a U-shaped dose-dependent reduction in impulsive actions.
- 1-(2-Pyriidinyl)-piperazine showed a modest decrease in impulsivity but also caused motor impairments.
Conclusions:
- The findings support the proposed strategy for identifying anti-impulsivity drugs.
- Further refinement of the strategy is necessary for the successful development of novel anti-impulsivity medications.
