Kidney function in minority children and adolescents with metabolically healthy and unhealthy obesity

Metabolic syndrome and/or body mass index (BMI) ≥40 kg/m² are risk factors for kidney function decline in the general population. To compare creatinine (Cr), estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN) between minority children and adolescents with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), a chart review was conducted on subjects aged 4 to 20 years with BMI ≥95^th percentile from July 2014 to April 2017. They were stratified into MHO and MUO groups. Cr, eGFR and BUN were studied. Total n = 277: MHO n = 105 vs MUO n = 172. Cr was higher and BUN was lower in MUO whereas eGFR did not differ between the groups. Using general linear model, we found that metabolic status predicted BUN (P = .009) but not Cr or eGFR. When age, sex and Tanner stage matched, BUN, Cr and eGFR were similar between the groups. Higher BUN in MHO could be due to higher dietary protein intake. Subjects were divided into BMI ≥40 vs <40 kg/m² , BUN and eGFR were not different. A trend towards higher Cr in those with BMI ≥40 kg/m² (P = .054) was found; the group being older and taller. After age and height matching, all outcomes were not different. Higher Cr was found in those with elevated blood pressures vs the MHO (P = .047). Those with diastolic blood pressure (DBP) ≥90^th percentile had higher Cr than those with systolic blood pressure ≥90^th percentile (P = .017). Children and adolescents with MUO, and those with BMI ≥40 kg/m² did not appear to have early diminished kidney function. Higher Cr, although in normal range, occurred in those with abnormal DBP.