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Receptor Functions of Semaphorin 4D
1Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences, Perm, 614081, Russia. ibis_07@mail.ru.
Biochemistry. Biokhimiia
|November 7, 2019
Summary
Semaphorin 4D (Sema4D) protein can act as a receptor, not just a ligand, to regulate cell functions. This review explores this alternative signaling pathway and its implications in various biological processes.
Area of Science:
- Molecular Biology
- Cell Signaling
- Immunology
Background:
- Semaphorin 4D (Sema4D) is a widely expressed protein involved in immunoregulation, neurogenesis, angiogenesis, and tumor progression.
- Traditionally, Sema4D is considered a ligand that binds to CD72 and plexin receptors.
Purpose of the Study:
- To analyze data suggesting an alternative mechanism of Sema4D regulatory activity.
- To explore Sema4D functioning as a receptor mediating outside-in signaling.
Main Methods:
- Review and analysis of existing scientific literature.
- Discussion of cell signaling pathways involving membrane-bound Sema4D.
Main Results:
- Evidence suggests Sema4D can function as a receptor, initiating outside-in signaling.
- This alternative mechanism contributes to Sema4D-dependent regulation of cellular functions.
Conclusions:
- Sema4D possesses a dual role as both a ligand and a receptor.
- Understanding this alternative receptor function of Sema4D is crucial for comprehending its diverse biological roles.
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